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  » Drug encyclopedia
Drug induced acceleration of metabolism of drugs    Inhibition of metabolism of a drug by another drug
Inducer Drugs whose metabolism is accelerated Inhibitor Drugs whose metabolism is inhibited
Barbiturates Barbiturates, oral anticoagulants, steroids (oral contraceptives, testosterone, glucocorticoids), vitamins (D and K), thyroxine, phenylbutazone, phenytoin, griseofulvin, chloramphenicol, theophylline Allopurinol Tolbutamide, methotrexate, probenecid.
Disulfiram Alcohol, tolbutamide, warfarin, phenytoin.
Isoniazid Glucocorticoids, oral contraceptives, carbamazepine, phenytoin
Chloramphenicol Tolbutamide, probenecid, phenytoin
Phenytoin Glucocorticoids, vitamin D, theophylline Cimetidine Warfarin, diazepam
Ketoconazole Cyclosporin, astemizole,terfenadine
Phenylbutazone Phenytoin, tolbutamide.
Phenylbutazone Glucocorticoids Ethanol Methanol (beneficial effect)
Griseofulvin Warfarin Macrolides Theophylline, glucocorticoids
Rifampicin Oral contraceptives, glucocorticoids, metoprolol, propranolol
Carbamazepine Vitamin D Grape fruit juice* Cyclosporin, terfenadine and most calcium channel blockers
Dicophane and gamma benzene hexachloride are powerful inducers of drug- metabolising microsomal enzymes. Hence, research on drug metabolism could be misleading. If the animal quarters are sprayed with either of these insectcides Many drugs inhibit the p-hydroxylation of phenytoin, increasing the chance of phenytoin toxicity. They inclulde dicumarol, isoniazid, sulfaphenazole, disulfiram, chloramphenicol and methylphenydate.
* Contains psoralen